Breztri Aerosphere is AstraZeneca’s triple-therapy inhaler, combining budesonide, glycopyrrolate and formoterol fumarate in a single pressurized metered-dose device. FDA approved it for COPD in 2020 and added a maintenance-treatment-of-asthma indication on April 28, 2026, so more people are being handed this prescription than a year ago.
The cash price story here has two completely different answers depending on one piece of paperwork. Walk into a pharmacy with nothing and you are looking at a figure between roughly $600 and $960 for a single inhaler. Walk in with AstraZeneca’s savings card and, if you are uninsured, the posted terms cap you at $35. Every number below was pulled on September 2, 2026.
What Does Breztri Cost Without Insurance?
The standard Breztri presentation is a 10.7 gram inhaler delivering 120 actuations at 160/9/4.8 mcg per puff, which at two inhalations twice a day is a 30-day supply. There is also a smaller 5.9 gram, 28-inhalation canister used for shorter fills.
| Option | Low | Average / typical | High |
|---|---|---|---|
| Breztri, average retail cash (no card) | $961.92 | $961.92 | $961.92 |
| Breztri, cash with a discount card | $596.43 | $626.43 | $706.12 |
| Breztri, lowest published cash quote, 10.7 g | $676.45 | $676.45 | $676.45 |
| CMS national acquisition cost, 10.7 g inhaler | $656.83 | $656.83 | $656.83 |
| Smaller 5.9 g / 28-inhalation canister | $376.56 | $376.56 | $376.56 |
| AstraZeneca $35 inhaler savings card | $35 | $35 | $35 |
| AZ&Me Prescription Savings Program | $0 | $0 | $0 |
The sources genuinely disagree on the middle of that range, and it is worth knowing why. SingleCare’s Breztri Aerosphere page, with prices updated September 2, 2026, states an average retail price of $961.92 for one 10.7 gram inhaler and a lowest card price of $596.43 once you create a free account ($626.43 without the signup bonus). The Drugs.com price guide for the same 10.7 gram inhaler starts at $676.45. CMS sits between them: the National Average Drug Acquisition Cost file effective August 19, 2026 prices Breztri Aerosphere at $61.38644 per gram, which works out to about $656.83 for the 10.7 gram canister.
NADAC measures what pharmacies pay to buy the drug, not what they charge you, so it is a floor rather than a shelf price. The practical read is that a cash counter quote anywhere from about $596 to $962 is inside the normal band, and anything meaningfully above that is worth challenging.
The $35 card, and exactly who it covers
AstraZeneca announced on March 18, 2024 that starting June 1, 2024 eligible patients would pay no more than $35 per month across its entire US inhaled respiratory portfolio, naming Airsupra, Bevespi Aerosphere, Breztri Aerosphere and Symbicort. The announcement specifically called out patients “who are uninsured and underinsured,” which is unusual and is the single most useful fact on this page.
The posted card terms back that up. They state that you may be eligible if you have commercial insurance that does not cover the full cost of your prescription, or if you are not insured and are responsible for the cost of your prescriptions. Eligible commercially insured patients with no restrictions, and uninsured patients, who present the card at participating pharmacies “will pay no more than $35 for each 30-day supply (1 inhaler),” subject to a maximum savings limit of wholesale acquisition cost plus usual and customary pharmacy charges.
Two limits matter. Patients enrolled in a state or federally funded prescription program are excluded, including Medicare Part D, Medicaid, Medigap, VA, DoD programs and TRICARE, and the terms explicitly say you may not use the card even if you elect to be processed as an uninsured cash-paying patient. And card savings are not valid for Massachusetts residents if an AB-rated generic is available, or for California residents if an FDA-approved therapeutic equivalent exists.
What Drives the Price
There is no generic and there will not be one soon. SingleCare’s page states no generic is currently available and puts the earliest possible arrival at 2038. FDA records list a single application for the product, NDA 212122 held by AstraZeneca AB. With no abbreviated applications behind it, there is nothing cheaper to switch the prescription to, which is why manufacturer programs carry all the weight here.
Which canister size the prescription is written for. The 5.9 gram, 28-inhalation canister runs $376.56 on the Drugs.com guide against $676.45 for the 10.7 gram, 120-inhalation version. Per day of therapy the small one is worse value, so confirm which one your prescriber wrote before you compare quotes.
Whether you have a card at all. The gap between the average retail price and the $35 card price is roughly $927 per inhaler per month. Nothing else on this page moves the number by more than a couple hundred dollars.
Your insurance type, not your income. Medicare and Medicaid enrollees are locked out of the manufacturer card by federal anti-kickback rules. That produces the odd result that an uninsured patient can pay less out of pocket for Breztri than a Medicare enrollee does.
Pharmacy and region. SingleCare’s own card prices for the identical inhaler spanned roughly $596 to $706 across pharmacies in a single ZIP code lookup, and its retail figures by chain ran from about $809 to $832. Same drug, same day, different counter.
Cash Price vs. Insurance
If you are uninsured, the cash-with-card route is almost certainly your cheapest path, and there is no situation in which paying $961.92 at the counter is the right move when the $35 card is open to you.
If you are commercially insured, it depends on plan design. A preferred-tier copay under $35 beats the card. A deductible phase, a coinsurance percentage or a step-therapy requirement usually does not, and in those cases the card is the better run. The catch is the same one that applies to every manufacturer program: assistance dollars often do not count toward your deductible or out-of-pocket maximum, and copay accumulator or maximizer programs are designed specifically to capture that money.
AstraZeneca Direct is worth knowing about as a logistics channel rather than a discount. Its program page, last updated August 2026, lists Breztri among the medicines your prescriber can e-prescribe to ASPN Pharmacies, which then verifies benefits, starts any prior authorization and applies available savings automatically before shipping to your home or transferring to a local pharmacy.
If a quote you get does not match anything on this page, our fair price checker will tell you fast whether it is inside a defensible range.
How to Pay Less
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Ask for the AstraZeneca $35 inhaler savings card by name. Per the posted terms, eligible uninsured patients pay no more than $35 for each 30-day supply. Against the $961.92 average retail price that is about $927 a month, and it is the single highest-value action on this list.
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Apply to AZ&Me if the card is closed to you. The AZ&Me Prescription Savings Program provides AstraZeneca medications at no cost to eligible patients who cannot afford them, including people covered under Medicare who still cannot pay, and it fills up to a 90-day supply delivered to your home or your doctor’s office. It is the main route for Medicare enrollees, who cannot use the card.
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Price the exact canister size at three pharmacies. The card-price spread SingleCare showed in one ZIP code was more than $100 on the identical inhaler. Our comparison of GoodRx vs. SingleCare covers how to check both cards against the same NDC in a couple of minutes.
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Compare against the other triple-therapy inhaler. Breztri and Trelegy Ellipta are priced within a few dollars of each other at retail and both manufacturers cap eligible patients at $35, so if one program rejects you the other may not. Our broader inhaler cost guide lines up the whole category, and Symbicort is the AstraZeneca dual-therapy option covered by the same $35 card.
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Budget the rescue inhaler separately. Breztri is maintenance therapy and is billed as its own prescription. Our guide to albuterol inhaler costs without insurance covers the other half of that bill.
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Get the prescribing visit priced too. A free or sliding-scale clinic can handle the pulmonology follow-ups that generate and renew this prescription at little or no cost. If a hospital or specialist bill has already landed, our medical bill negotiation guide covers what to say before you pay it.
Bottom Line
Budget $596 to $962 for a 30-day Breztri Aerosphere inhaler if you pay cash with nothing but a discount card in September 2026. CMS acquisition data puts the pharmacy’s own cost at about $657 for the same canister, which tells you how much of that spread is markup.
If you qualify for AstraZeneca’s inhaler savings card, the number drops to $35, and AZ&Me can take it to zero for patients who meet the income criteria. With no generic possible before 2038, the entire question on this drug is which program will accept you, and the answer turns on your insurance type more than on what you earn.