Humira (adalimumab) is a TNF-inhibitor biologic that was, for a decade, the best-selling prescription drug in the world. It is injected under the skin, sold in cartons of two prefilled pens or syringes, and it has spent most of its U.S. life priced in the mid four figures per carton.
That is no longer the whole story. Ten adalimumab biosimilars have been licensed by FDA since 2016, most of them launched into U.S. pharmacies starting in 2023, and several are sold at a fraction of Humira’s price. The gap between the brand and the cheapest biosimilar is now larger than the entire cash price of most prescriptions on this site. This guide prices both sides of that gap as verified on September 1 and 2, 2026, and it is about money only. Whether a biosimilar is an option for you is a conversation with your prescriber and pharmacist.
What Does Humira Cost Without Insurance?
Retail figures below come from SingleCare’s live drug pages, updated September 2, 2026. Cost Plus Drugs figures are that pharmacy’s published home-delivery prices as displayed on September 1, 2026. All prices are for a standard carton of two 40 mg autoinjectors or syringes unless noted.
| Product | Low | Average / typical | High |
|---|---|---|---|
| Humira, cash with a discount card | $6,042.35 (Kroger, Harris Teeter) | $6,422 (Publix) | $7,069 (Food Lion) |
| Humira, no card (average retail) | $8,794.75 | $8,794.75 | $8,794.75 |
| Adalimumab-fkjp, Cost Plus home delivery | $423.25 | $423.25 | $979.82 (retail comparison) |
| Adalimumab-aacf, Cost Plus home delivery | $469.25 | $469.25 | $897.90 (retail comparison) |
| Yusimry, Cost Plus home delivery | $526.75 | $526.75 | $995.00 (retail comparison) |
| Hadlima and Hadlima PushTouch, Cost Plus | $1,196.76 | $1,196.76 | $2,011.08 (retail comparison) |
| Amjevita, cash with a discount card | $1,233.92 (Walgreens) | $1,356.74 (Kroger) | $1,464.79 (Costco) |
| Adalimumab-adaz, cash with a discount card | $1,254.80 | $1,254.80 | $1,328.83 (Publix) |
| Humira Complete Savings Card (commercial insurance only) | $0 | $0 | $0 |
| myAbbVie Assist (income-qualified) | $0 | $0 | $0 |
Two numbers frame everything else. Humira’s average retail cash price is $8,794.75 per carton. The cheapest adalimumab on Cost Plus Drugs is $423.25. That is a spread of more than $8,300 per carton for the same active ingredient.
List price vs. what the counter charges
Organon and Samsung Bioepis publish both drugs’ wholesale acquisition cost on the official Hadlima patient site: $1,038 per carton for Hadlima against $6,922.62 per carton for Humira, stated as of October 2023. That is an 85% discount at the list-price level, and it is the clearest manufacturer-published comparison available.
Note the vintage. That disclosure is nearly three years old as of September 2026, and SingleCare’s current average retail price for Humira sits about $1,870 above the 2023 WAC figure, which is normal because retail cash prices include pharmacy markup on top of acquisition cost. Treat $6,922.62 as the last confirmed manufacturer list price rather than today’s number, and treat the $6,042 to $8,795 range as what a counter actually charges.
What the biosimilars actually cost
FDA’s biosimilar product list, current as of August 4, 2026, shows ten adalimumab products licensed against Humira: Amjevita (September 2016), Cyltezo (August 2017), Hyrimoz (October 2018), Hadlima (July 2019), Abrilada (November 2019), Hulio (July 2020), Yusimry (December 2021), Idacio (December 2022), Yuflyma (May 2023) and Simlandi (February 2024).
Several of those are sold two ways: as a branded biosimilar and as a cheaper unbranded version carrying only the nonproprietary name. That distinction is where the real money is. On Cost Plus Drugs, adalimumab-fkjp (the unbranded form of Hulio) is $423.25 for home delivery and adalimumab-aacf (unbranded Idacio) is $469.25, while branded Hadlima on the same site is $1,196.76.
At retail pharmacies the branded biosimilars sit in the middle. SingleCare’s September 2, 2026 data shows Amjevita at a typical cash price of $1,877.03 with card prices from $1,233.92 at Walgreens to $1,464.79 at Costco, and adalimumab-adaz (unbranded Hyrimoz, from Sandoz) at $2,078.34 average retail with a card price of $1,254.80.
What Drives the Price
Brand vs. biosimilar vs. unbranded biosimilar. This is the single biggest lever, worth thousands of dollars per carton. Same molecule, three price tiers, and the unbranded tier is consistently the cheapest.
Where you buy. A direct-to-consumer pharmacy that publishes a flat cash price behaves nothing like a retail counter. Cost Plus Drugs prices adalimumab-fkjp at $423.25 while showing a $979.82 retail comparison for the same product, and Humira itself is not sold there at all.
Which pharmacy chain, if you use a counter. SingleCare’s Humira prices swing from $6,042.35 at Kroger and Harris Teeter to $7,069 at Food Lion, a $1,026 gap on an identical carton. Walgreens sits at $6,376.38, Publix at $6,422 and Costco at $6,582.31.
Your insurance status, in both directions. The $0 savings card requires commercial insurance. The free-drug program requires limited or no insurance plus a qualifying income. Being commercially insured with a plan that excludes the drug puts you between the two.
Formulary politics. Plans and pharmacy benefit managers decide which adalimumab products they cover and at what tier, which is why an insured patient sometimes pays more out of pocket for a cheaper biosimilar than for the brand. That is a coverage question to raise with your plan, not something you can fix at the register.
Cash Price vs. Insurance
If you have commercial insurance that covers Humira, the manufacturer card is the best deal available. AbbVie’s Humira Complete Savings Card advertises Humira for as little as $0 per month for eligible commercially insured patients, with a maximum of $14,000 in assistance per calendar year. For rheumatology patients the benefit can also cover one additional medication (methotrexate, leflunomide or hydroxychloroquine).
The exclusions are broad, though. Anyone with Medicare (including Part D), Medicare Advantage, Medigap, Medicaid, TRICARE, Department of Defense or Veterans Affairs coverage is barred from the card by federal rules. So are patients whose insurers run accumulator adjustment or co-pay maximizer programs, which are designed to capture manufacturer assistance rather than pass it to you.
For everyone else, cash is not automatically the worse option. A biosimilar bought outright for $423 to $527 can beat an insured fill on a high-deductible plan early in the year, when you would be paying the full negotiated price toward the deductible anyway. The tradeoff is that self-pay dollars usually do not count toward your deductible or out-of-pocket maximum, so run the math for the full year rather than one carton. Our fair price checker is a fast sanity check on any figure a pharmacy quotes you.
How to Pay Less
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Ask your prescriber whether a biosimilar or unbranded adalimumab is written into your prescription. Pharmacists cannot always substitute automatically, and the difference between the brand and the cheapest unbranded product on Cost Plus Drugs is more than $8,000 per carton. This is a clinical decision, so bring the price list and let your prescriber make the call.
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Price the specific product at a direct-to-consumer pharmacy before you use a counter. Cost Plus Drugs publishes its adalimumab prices openly, which is unusual for a biologic and makes it a useful benchmark even if you fill elsewhere.
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Run both discount cards on whatever you do fill locally. SingleCare’s own data shows a $1,026 swing on Humira between chains. Our comparison of GoodRx vs. SingleCare walks through checking both on the same NDC in a couple of minutes.
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Apply to myAbbVie Assist if your income qualifies. AbbVie’s published ceiling is $63,840 for a household of one, $86,560 for two, $109,280 for three and $132,000 for four, plus $22,720 for each additional dependent, and the program provides AbbVie medicines at no cost to approved applicants with limited or no coverage. Patients pushed into the program by a commercial plan’s alternate funding arrangement are not eligible.
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Use the manufacturer card if you are commercially insured, and check the annual cap. The $14,000 per calendar year maximum is generous but finite against a drug priced near $7,000 a carton, so know where you stand mid-year.
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Do not overlook the visits and labs that come with the prescription. A free or sliding-scale clinic can handle prescribing and monitoring visits at little or no cost, and if a specialist bill has already landed, our medical bill negotiation guide covers what to say before you pay it.
Bottom Line
Budget $6,042 to $8,795 per carton if you fill brand-name Humira at a U.S. pharmacy counter in September 2026, roughly $1,234 to $1,465 for a branded biosimilar like Amjevita with a discount card, and $423 to $527 if you buy unbranded adalimumab or Yusimry through Cost Plus Drugs. Two programs take the number to zero for people who qualify: the Humira Complete card for the commercially insured, and myAbbVie Assist for people under the published income limits.
The reason this page exists is that the biosimilar market finally did what it was supposed to do. A drug that had no cheaper equivalent for twenty years now has ten, and the price difference is not marginal. For other high-cost brand prescriptions with the same dynamic, see our guides to Eliquis, Xarelto and Entresto. If you are managing a chronic respiratory condition alongside this one, Trelegy has its own $35 manufacturer cap worth knowing about.